Evaluation of drilling parameters on thrust force in drilling carbon fiber reinforced plastic (CFRP) composite laminates using compound core-special drills

Drilling is the mostly used secondary machining of the fiber reinforced composite laminates, while the delamination occurs frequently at the drill exit in the workpiece. In the industrial experiences, core drill shows better drilling quality than twist drill. However, chip removal is a troublesome problem when using the core drill. Conventional compound core-special drills (core-special drills and step-core-special drills) are designed to avoid the chip removal clog in drilling. But the cutting velocity ratio (relative motion) between outer drill and inner drill is null for conventional compound core-special drills. The current study develops a new device and to solve the problems of relative motion and chip removal between the outer and inner drills in drilling CFRP composite laminates. In addition, this study investigates the influence of drilling parameters (cutting velocity ratio, feed rate, stretch, inner drill type and inner drill diameter) on thrust force of compound core-special drills. An innovative device can be consulted in application of compound core-special drill in different industries in the future.     

A three-dimensional eigenfunction expansion approach for singular stress field near an adhesively-bonded scarf joint interface in a rigidly-encased plate

A three-dimensional eigenfunction expansion approach for determination of the singular stress field in the vicinity of an adhesively-bonded scarf joint interface in a plate, with its top and bottom surfaces being encased, fully or partially, between infinitely rigid blocks is presented. The plate is subjected to extension/bending (mode I) and in-plane shear/twisting (mode II) far-field loading. Both the adhesive layer and plate materials are assumed to be isotropic and elastic. The boundary conditions that are prescribed on the end-faces (free, fixed and lubricated) of the plate as well as those, prescribed at the bottom or top surface of the scarf-bonded plate on either side of the interface between the plate and adhesive layer materials (fixed-fixed, free-fixed and fixed-free), are exactly satisfied. Numerical results include the dependence of the lowest eigenvalue (or most severe stress singularity) on the wedge aperture angle of the plate material. Variation of the same with respect to the shear moduli ratio of the constituent plate and adhesive layer materials is also an important part of the present investigation. Hitherto unobserved interesting and physically meaningful conclusions in regards to the fixed edge singularity and delamination type flaw sensitivity of an adhesively bonded plate surface are also presented. Finally, hitherto unavailable results, pertaining to the through-width variations of stress intensity factors corresponding to symmetric and skew-symmetric sinusoidal loads that also satisfy the boundary conditions on the end-faces of the adhesively bonded plate, in the vicinity of the scarf joint interface, under investigation, bridge a longstanding gap in the bonded joint stress singularity/fracture mechanics literature.     

In vivo absorption comparison of nanotechnology-based silybin tablets with its water-soluble derivative

In this study, the in vivo oral absorption of a nanocrystal tablet formulation of a BCS II poorly water-soluble drug was compared with that of its water-soluble salt form. Silybin is used as the model drug, and its nanosuspension was prepared by high-pressure homogenization. Effect of process and formulation parameters on properties of the nansuspensions was investigated. Dried powder of the nanosuspension was prepared by spray drying and used for preparing tablets. A pharmacokinetic study was performed in Beagle dogs to compare the absorption for tablets of silybin nanocrystals and silybin meglumine. In vivo absorption of nanocrystal silybin tablet in Beagle dogs was determined. X-ray powder diffraction results indicated that silybin existed in a crystalline state after homogenization. In vivo absorption study in rats showed that the peroral absorption of silybin was enhanced remarkably by decreasing particle size. In vivo absorption of nanocrystal silybin tablet in Beagle dogs was comparable with that of the commercially available tablet of the water-soluble salt form of silybin. In conclusion, it is possible to increase the bioavailability of poorly soluble drugs by preparing its water-soluble derivative.     

Emotional costs of inaccurate self-assessments: Both self-effacement and self-enhancement can lead to dejection.

Despite the popularity of the idea in American culture that self-enhancement confers psychological benefits, the evidence for this idea is mixed. In the present research, we tested the contention that overly positive self-assessments could lead to psychological distress. In two correlational studies (Studies 1 and 2), we addressed some previous problems related to the measurement of self-enhancement. By measuring self-enhancement through the discrepancy between self-assessments of relative task performance and actual relative task performance, we found that self-enhancement, like self-effacement, was associated with greater vulnerability to depression. In two subsequent experiments (Studies 3 and 4), we found that leading low (or high) performers to perceive their performance as high (or low) through providing bogus performance feedback produced analogous effects on the magnitude of experienced dejection. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Preparation and characterization of methoxy‐poly(ethylene glycol) side chain grafted onto chitosan as a wound dressing film

Chitosan has received extensive attention as a biomedical material; however, the poor solubility of chitosan is the major limiting factor in its utilization. In this study, chitosan‐based biomaterials with improved aqueous solubility were synthesized. Two molecular weights (750 Da and 2000 Da) of methoxypoly(ethylene glycol) (mPEG) were grafted onto chitosan (mPEG‐g‐chitosan) to form a ～100‐μm‐thick plastic film as a wound dressing. The chemical structures of the mPEG‐g‐chitosan copolymers were confirmed using Fourier transform infrared spectroscopy (FTIR), and the thermal properties were characterized using thermogravimetry analysis (TGA). Their microstructures were observed using scanning electron microscopy (SEM). The other properties were analyzed via the swelling ratio, tensile strength, elongation, and water vapor transmission rate (WVTR). Biocompatibility evaluations through biodegradability, cytotoxicity, and antimicrobial effect studies were also performed. The obtained mPEG‐g‐chitosan copolymers were soluble in slightly acidic aqueous solutions (pH～6.5) at a concentration of 10 wt %. The optimal mPEG‐g‐chitosan hydrogels had swelling ratios greater than 100% and WVTRs greater than 2000 g/m²/day. Their performance against Staphylococcus aureus will be subjected to further improvements with respect to medical applications. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42340.     

Taurine ameliorates alcoholic steatohepatitis via enhancing self-antioxidant capacity and alcohol metabolism

Chronic alcohol consumption or alcohol abuse is the main cause of alcoholic steatohepatitis or further cirrhosis. This study was to exam if the antioxidant capacity and alcohol metabolism in livers of chronic alcohol-fed rats were improved by supplementing taurine (Tau). Rats were randomly divided into four groups with five times per week of treatment: 1) isocaloric solution; 2) 3 g alcohol/kg BW/day; 3) 3 g alcohol/kg BW/day + 1 g taurine (Tau)/kg BW/day; and 4) 3 g alcohol/kg BW/day + 2 g Tau/kg BW/day. A 6-week alcohol consumption resulted in lower (p < 0.05) body weight gain and self-antioxidant capacities, as well as increased (p < 0.05) liver size, serum/hepatic lipids, and AST and ALT values. However, alcohol-fed rats co-treated with Tau have decreased (p < 0.05) liver lipid levels via increasing fecal lipid output and cholesterol metabolism. Besides, co-treatment of Tau also enhanced (p < 0.05) self-antioxidant capacities and alcohol metabolism in livers via enhancing GSH contents, CAT, GSH-Px, ADH, and ALDH activities, but decreasing MDA contents. In a histological examination of rat liver, microvesicular steatosis and necrotic cells were observed in alcohol-fed rats without Tau while largely suppressed microvesicular steatosis and no necrotic cells were observed in alcohol-fed rat supplemented with Tau. Therefore, Tau could be an effective hepatoprotective agent against alcohol-induced damage via enhancing self-antioxidant capacity and alcohol metabolism.     

The Electro-Optical Effect of LC Cells by the Processing Parameter of PI Alignment Layer

The electro-optic characteristics of Liquid Crystal Displays (LCDs) are deeply affected by those parameters including the kinds of liquid crystals and alignment layer materials, the forming conditions of alignment layer, the substrates alignment mode and the processing conditions of rubbing alignment in the interface treatment. In this study, differential scanning calorimeter (DSC), thermal gravity analysis (TGA) and moisture analyzer are utilized to examine the properties of liquid crystals and PI alignment layer materials. The interface treatment between liquid crystals and PI alignment layers were executed via the alignment technology of unidirectional mechanical rubbing with a rayon velvet cloth. Those LC cell specimens were fabricated using Merck MJ99159 N_P liquid crystal and PI alignment layer material (JSR-AL 21000) with various process conditions. Under those parameters influence of curing, rubbing and alignment direction, cell specimens display various electric-optical effects.